2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1480S2
    (-)-Fucose-13C-2 478518-50-2 98%
    (-)-Fucose-13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-2
  • HY-N1480S3
    (-)-Fucose-13C-3 478518-51-3 98%
    (-)-Fucose-13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-3
  • HY-N15475A
    5β-Pregnane-3α,20α-diol 3-sulfate sodium 24136-02-5
    5β-Pregnane-3α,20α-diol 3-sulfate sodium is a steroid sulfate found in human urine and plasma.
    5β-Pregnane-3α,20α-diol 3-sulfate sodium
  • HY-N15691A
    (E)-Tadehaginoside 283176-41-0
    (E)-Tadehaginoside is the E-isomer of Tadehaginoside (HY-N15691). Tadehaginoside, a phenylpropanoid glycoside, is a regulator of lipogenesis and glucose consumption. Tadehaginoside has antioxygenic property. Tadehaginoside mediates liver protection against oxidative stress injury and inflammation by regulating Nrf2 and NF-κB signaling pathways in hepatocytes. Tadehaginoside can be used for the study of obesity and diabetes.
    (E)-Tadehaginoside
  • HY-N16588A
    trans-Emodin-physcion bianthrone 1085706-33-7
    trans-Emodin-physcion bianthrone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 2.77 μM. trans-Emodin-physcion bianthrone is applicable to research related to insulin resistance.
    trans-Emodin-physcion bianthrone
  • HY-N17761A
    Tetrandrine 2'-N-β-oxide 62828-25-5 98%
    Tetrandrine 2'-N-β-oxide is an anti-hyperglycemic dibenzylisoquinoline alkaloid. At a dose of 1 mg/kg, Tetrandrine 2'-N-β-oxide can reduce hyperglycemia levels in streptozotocin (HY-13753)-induced diabetic mice to nearly 50% of their original levels. Tetrandrine 2'-N-β-oxide is primarily used in research related to the anti-hyperglycemic of type 2 diabetes.
    Tetrandrine 2'-N-β-oxide
  • HY-N17882A
    Hydroxysaikosaponin D 173559-75-6 98%
    Hydroxysaikosaponin D is a hepatocytoprotective saponin found in the roots of Bupleurum scorzonerifolium WILLD. Hydroxysaikosaponin D inhibits D-galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Hydroxysaikosaponin D mitigates D-galactosamine/LPS-induced liver injury in mice. Hydroxysaikosaponin D can be used for the research of liver injury.
    Hydroxysaikosaponin D
  • HY-N1902S2
    4-Hydroxyphenylacetic acid-d2
    4-Hydroxyphenylacetic acid-d2 is the deuterium labeled 4-Hydroxyphenylacetic acid (HY-N1902). 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2.
    4-Hydroxyphenylacetic acid-d2
  • HY-N1981S2
    Triolein-13C3-1 1246739-64-9 98%
    Triolein-13C3-1 is the isotope labeled Triolein. Triolein is a symmetric triacylglycerol that reduces?upregulation of?MMP-1?and has strong antioxidant and anti-inflammatory activities
    Triolein-13C3-1
  • HY-N2362S5
    DL-Alanine-15N 71261-64-8 98%
    DL-Alanine-15N is the 15N labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.
    DL-Alanine-15N
  • HY-N2362S7
    DL-Alanine-13C3-4 144476-54-0
    DL-Alanine-13C3-4 (DL-2-Aminopropionic acid-13C3-4) is the 13C-labeled DL-Alanine (HY-N2362). DL-Alanine, an orally active amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver.
    DL-Alanine-13C3-4
  • HY-N3686S1
    D-Arabitol-13C-1 98%
    D-Arabitol-13C-1 is the 13C labeled D-Arabitol. D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research.
    D-Arabitol-13C-1
  • HY-N3686S2
    D-Arabitol-13C-2 98%
    D-Arabitol-13C-2 is the 13C labeled D-Arabitol. D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research.
    D-Arabitol-13C-2
  • HY-N5134S1
    5'-Guanylic acid-13C10 dilithium 98%
    5'-Guanylic acid-13C10 (5'-GMP-13C10 dilithium; 5'-guanosine monophosphate-13C10) dilithium is 13C-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
    5'-Guanylic acid-13C10 dilithium
  • HY-N5134S3
    5'-Guanylic acid-d12 dilithium 98%
    5'-Guanylic acid-d12 (5'-GMP-d12 dilithium; 5'-guanosine monophosphate-d12) dilithium is deuterium labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
    5'-Guanylic acid-d12 dilithium
  • HY-N6740S1
    β-Zearalanol-13C18
    β-Zearalanol-13C18 is the 13C-labeled β-Zearalanol. Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid.
    β-Zearalanol-13C18
  • HY-N6740S2
    Beta-Zearalanol-d5 98%
    Beta-Zearalanol-d5 is the deuterium labeled Beta-Zearalanol (HY-N6740). Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells. Beta-Zearalenol is the derivative of Zearalenone (HY-103447) which can conjugate with glucuronic acid.
    Beta-Zearalanol-d5
  • HY-P10697B
    H-PEG6-VH4127-NH2 98%
    H-PEG6-VH4127-NH2 is a VH4127 (HY-P10697) derivative that facilitates further conjugation with proteins.
    H-PEG6-VH4127-NH2
  • HY-P2625S1
    GLP-2(3-33) (Leu-13C6,15N) TFA 98%
    GLP-2(3-33) (Leu-13C6,15N) TFA is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
    GLP-2(3-33) (Leu-13C6,15N) TFA
  • HY-P990160
    Anti-Rat TCR alpha/beta Antibody (R73) 98%
    Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β+ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes.
    Anti-Rat TCR alpha/beta Antibody (R73)
Cat. No. Product Name / Synonyms Application Reactivity